منابع مشابه
Measurement of glutathione transport.
This unit provides methods for analyzing uptake in rat kidney proximal tubule cells and rat kidney cortical mitochondria, preparation of proximal tubule cells and cortical mitochondria, and HPLC analysis of glutathione and related compounds.
متن کاملHepatic glutathione and glutathione S-conjugate transport mechanisms.
Glutathione (GSH) plays a critical role in many cellular processes, including the metabolism and detoxification of oxidants, metals, and other reactive electrophilic compounds of both endogenous and exogenous origin. Because the liver is a major site of GSH and glutathione S-conjugate biosynthesis and export, significant effort has been devoted to characterizing liver cell sinusoidal and canali...
متن کاملTransport of glutathione-conjugates in human erythrocytes.
The last step of detoxification of both endogenous and environmental toxicants is typically a conjugation that produces a bulky hydrophilic molecule. The excretion of such conjugates out of cells is of sufficient biological importance to have led to the evolution of ATP-driven export pumps for this purpose. The substrate specificity of such transporters is broad, and in some cases it has been s...
متن کاملHepatobiliary transport of glutathione and glutathione conjugate in rats with hereditary hyperbilirubinemia.
TR- mutant rats have an autosomal recessive mutation that is expressed as a severely impaired hepatobiliary secretion of organic anions like bilirubin-(di)glucuronide and dibromosulphthalein (DBSP). In this paper, the hepatobiliary transport of glutathione and a glutathione conjugate was studied in normal Wistar rats and TR- rats. It was shown that glutathione is virtually absent from the bile ...
متن کاملRadioprotection by glutathione ester: transport of glutathione ester into human lymphoid cells and fibroblasts.
Glutathione is not effectively transported into human lymphoid cells, normal human skin fibroblasts, and fibroblasts from patients with genetic deficiencies of gamma-glutamylcysteine synthetase or glutathione synthetase. On the other hand, the monoethyl ester of glutathione, in which the carboxyl group of the glycine residue is esterified, is readily transported into these cells and is hydrolyz...
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ژورنال
عنوان ژورنال: membrane
سال: 1987
ISSN: 0385-1036,1884-6440
DOI: 10.5360/membrane.12.180